The Effect of Diazoxide on Ultrastructural Changes Following Ischemia-Reperfusion Injury of Rat Brain

Authors

  • Ali Hoseini Tehrani School of Medicine, Azad University
  • Majid Katebi Department of Anatomy, School of Medicine, Hormozgan University of Medical Sciences
  • Mansoure Soleimani Department of Anatomy, School of Medicine, Iran University of Medical Sciences
  • Mehdi Mehdizadeh Department of Anatomy, School of Medicine, Iran University of Medical Sciences
  • Mohammad Hassan Farahani Pad School of Medicine, Azad University
  • Mohammad Taghi Joghataei Department of Anatomy, School of Medicine, Iran University of Medical Sciences
Abstract:

A B S T R A C T Introduction: Even today there is no effective drug therapy to prevent neuronal loss after brain stroke. In the present study we studied the effect of mitochondrial KATP channel regulators on neuronal ultrastructure after ischemia reperfusion in the rat. Materials & Methods: Rats temporarily subjected to four vessels occlusion for 15 minutes followed by 24 hours reperfusion with or without K-ATP channel regulators. Results: Neuronal ultrastructure significantly improved in K-ATP channel opener (diazoxide) treated ischemia-reperfusion group compared with control group. Discussion: Our results showed that dizoxide treatment after ischemia reperfusion leads to better preservation of cortical neurons in rat.

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Journal title

volume 1  issue 3

pages  17- 20

publication date 2010-05

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